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Photoinduced cleavage of biological/chemical compounds

In the framework of an iba internal strategic project and by financial support of the DAAD (RISE Professional Program) a promising, but also simple molecular architecture was developed enabling the photoinduced release of chemical compounds with primary amines based on one- and two-photon absorption. Silane coupling to the surface and biotin/streptavidin chemistry ensure the stability of the system. Imaging ellipsometry demonstrates the intensity dependent release of the model compound.

a, b) Thickness map of (2D und 3D) of a few nm thick covalently bound aminosilane layer on a SiO2 substrate.  Photopatterning visualizes the the organic layer. The photolabile linker architecture was bound to the amino functional groups. c) 2-photon excitation releases the model compound bearing an primary amine can be released. (Imaging ellipsometry)

[1] X. Wang, S. Werner, T. Weiß, K. Liefeith and C. Hoffmann: ortho-Nitrobenzyl alcohol based two-photon excitation controlled drug release system. RSC Advances 2 (1/2012) 156-160.
[2] K. Schmitt, J. Rist and C. Hoffmann: Optical waveguides for evanescent wave induced cleavage of photolabile linker compounds, Anal. Bioanal. Chem. 401 (2/2011) 777-782.
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