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The Institute for Bioprocessing and Analytical Measurement Techniques is an application-oriented, non-university research institute of the Free State of Thuringia and an affiliated Institute of the Ilmenau Technical University with a highly developed technical infrastructure. Our stringent interdisciplinary high-level research focus “Biotechniques at Interfaces” aims for “Engineering of Molecular and Cellular Procedures for Disease Modeling”. Special topics are e.g. personalized and early diagnosis of diseases, follow-up of therapies, the impact of therapeutic drugs and influence of biofilms on human health by means of 3D cell models in combination with smart technical materials as scaffolds. Basic technologies of our research are fast broadband bio-impedance spectroscopy, drop-based microfluidics and functionalization of bio-interfaces, established in three departments with about 60 employees.

For the work of the junior research group of 3D cell structures and smart materials for disease modelling and in cooperation with the PhD Students of the Institute we are looking for a

Postdoc

on

 Characterization of Platelet factor 4-Polyanion Complexes and Corresponding Pathogenic Antibodies.

Recently, biophysical properties of human anti-PF 4/polyanion antibodies (aPF4/P Abs) that induce heparin-induced thrombocytopenia (HIT) have been successfully characterized (https://www.nature.com/articles/ncomms14945). This project focuses on further understanding the pathogenesis of HIT. In particular, the interactions of human antibodies with cell membranes, PF4/P complexes formed by mutant PF4s or reactivity of monoclonal aPF4/P Abs antibodies will be investigated. The use of these materials may allow establishing a methodology to distinguish between clinically relevant and non-relevant aPF4/P Abs. The test system can then be further developed for use in the routine clinical laboratory. The postdoc also addresses the pathogenesis of heparin-induced thrombocytopenia based on the interaction between PF4 and von Willebrand factor and the possibility that aPF4/P Abs interfere with the cleavage of high molecular weight von Willebrand multimers by the enzyme ADAMTS13.

The high sensitivity methodologies such as electrical impedance spectroscopy, single-molecule force spectroscopy-based AFM, Fluorescent microscopy, CD spectroscopy, Isothermal calorimetry, Dynamic light scattering, and enzyme immunoassays, etc. will be utilized.

Prerequisites are a completed Ph.D. degree in biology, chemistry, biochemistry, biophysics, physical chemistry or comparable disciplines and experienced preferably in highly sensitivity methodologies, skilled in proteins and blood cells. Self-responsible and conscientious working methods, safe manner, presentation skill, team-work, ability in spoken and written German and English are among your strengths.

iba offers its highly developed technical equipment and infrastructure, a pleasant and professional working environment in an interdisciplinary and international constituted research team, opportunities to cooperate with other research groups and institutions and an exciting research field with ample opportunities to employ creativity. Work life balance is ensured by flexible work time.

The Postdoc position is initially limited to two years. The salary will be based upon German TV-L rules with E 13. Our institute strives to increase the number of female employees and urges qualified female scientists to apply. For more information, please contact the head of the junior research group, Dr. Thi-Huong Nguyen (thi-huong.nguyen@iba-heiligenstadt.de).

Please send your application with the usual documents and the subject "Postdoc-X04/2019" until 22.07.2019 to:

 


Institut für Bioprozess- und Analysenmesstechnik e. V.

Rosenhof

D-37308 Heilbad Heiligenstadt

bewerbung(at)iba-heiligenstadt.de

www.iba-heiligenstadt.de

 

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iba e.V. | Rosenhof | 37308 Heilbad Heiligenstadt | +49 (0) 3606 / 671 - 0 | iba(at)iba-heiligenstadt.de | typo3 hannover  microsoft crm add on