Forschungsprojekte

Novel biomimetic strategy for bone regeneration (InnovaBone) 

Fördermittelgeber:

EU, FP7-NMP-2010-LARGE-4, Grant Agreement No 263363

Bearbeitungszeitraum:

2011-2015

Partner:

Universität Wien, Österreich
University of Cambridge, United Kingdom
University of Nottingham, United Kingdom
Qserve Consultancy BV, Netherlands
Baxter Innovations GmbH, Wien, Österreich
Tetra Gesellschaft für Sensorik, Robotik und Automation mbH, Ilmenau
CSEM Centre Suisse D'electronique et de Microtechnique SA, Neuchatel, Suisse
Medizinische Universität Wien, Österreich
Universidad de Valladolid, Spain
Universitat Politecnica de Catalunya, Barcelona, Spain
Universitätsmedizin Göttingen
Moverim Consulting SPRL, Bruxelles, Belgium
Promoscience srl, Trieste, Italy

Projektleiter:

Prof. Dr.-Ing. Klaus Liefeith

The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Gur overall approach is to produce smart bioactive 3D scaffolds to fit within bone lesions, which we will then inject with functional, genetically-engineered self-solidifying elastin-like polymers with absolute-controlled molecular architecture and sequences containing specific domains for cell attachment, growth factors and calcium phosphate nanoparticles. The resulting bioactive, biodegradable scaffolds, biogels and regenerated bone will be analysed for biomaterial effects on bone growth, healing, foreign body reactions using cutting-edge in vitro assays, BioMEMS technology, in vive animal models, non-invasive imaging and gene expression profiling for discovery of biomarkers associated with bone repair. Biomaterials will also be tested with biodynamic assays to assess strength, durability, toxicology, sterilisation reaction, eco-toxicology and risk assessment. Gur multidisciplinary consortium with its extensive, state-of-the-art expertise consisting of private and public partners, cellular and molecular biologists, immunologists, physicists, bioengineers, and orthopaedic surgeons will tackle serious bone lesions with a comprehensive work plan to develop a prototype, evaluate it in vivo and in vitro, upscale its production and prepare the final material for clinical phase trials and commercialisation of the dual component product. Gur ultimate aims are to ensure strong, healthy bone regeneration, reduce pain and suffering and to become a competitor in the biomaterials market of Europe.

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