Fachbereich Biowerkstoffe

BMBF: Bundesministerium für Bildung und Forschung
BMWi: Bundesministerium für Wirtschaft und Energie
DFG: Deutsche Forschungsgemeinschaft
EU-Kommission: Europäische Kommission
TMWWDG: Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft

1. Braun, F., et al.:Sustainable Fabrication of Tailored Bone Substitutes: From High-Throughput Scaffold Manufacturing, Scaled-Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor. Advanced Science, 2026. n/a(n/a): p. e23846.
2. Börke, J.M., et al.:Model System for Investigating Glycocalyx-Relevant Hydration Phenomena. ACS Appl Mater Interfaces, 2026. 18(15): p. 22537-22551.
3. Sokoliuk, D., et al.:Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems. Eng Life Sci, 2026. 26(1): p. e70059.
4. Hoffmann, T., et al.:RGD Modification of Poly(2-oxazoline) Cryogels: Investigation of Material Properties and Cellular Adhesion. Macromol Biosci, 2026. 26(1): p. e00421.
5. Kauffmann, P., et al.:Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity-An Experimental In-Vivo Study. Clin Oral Implants Res, 2026. 37(1): p. 1-17.
6. Alt, F., et al.:Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche. Biotechnol Bioeng, 2026.
7. Guder, C., et al.:4D degradation analysis of gelatin-modified calcium/strontium phosphate bone substitutes with µCT-flow chamber. Journal of Materials Research, 2026. 41(8): p. 1269-1285.
8. Alt, F., et al.:Multifactorial design considerations for 3D-Printed PCL-CaCO3 bone graft scaffolds: mechanical, degradation, and electrical field-related aspects. Materials & Design, 2026. 267: p. 116324.
9. Czich, S., et al.:Improving the biocompatibility of photo-crosslinkable poly(2-oxazoline)-based hydrogels for stem cell research. Materials & Design, 2026. 268: p. 116372.
10. Jalali, S., et al.:Dual-component nanofiber scaffolds of silica and collagen for enhanced mechanical integrity and osteogenic bioactivity. Materials & Design, 2025. 260: p. 115249.
11. Hoffmann, T., et al.:Adjustment of physical properties and pH-responsive behavior of cryogels based on two- and three-armed poly(2-oxazoline) cross-linkers with functional side chains. European Polymer Journal, 2025. 235: p. 114031.
12. Kauffmann, P., et al.:Effect of Sequential vs. Simultaneous Dual Growth Factor Release from Structured Heparin-Poly-Electrolyte Multilayer Coatings on Peri-Implant Bone Formation and Angiogenesis in Pig Mandibles. J Funct Biomater, 2025. 16(2).
13. Wunderer, M.S., et al.:Poly-(D,L)-Lactide-epsilon-Caprolactone-Methacrylate Is a Suitable Scaffold Material for In Vitro Cartilage Regeneration. Int J Mol Sci, 2025. 26(12).
14. Schirmer, U., et al.:Sclerostin Alters Tumor Cell Characteristics of Oral Squamous Cell Carcinoma and May Be a Key Player in Local Bone Invasion. Cells, 2024. 13(2).
15. Mair, V., et al.: Fabrication of biodegradable tailor-made bone cartilage implants by TPA. in AMMM 2023: Additive Manufacturing Meets Medicine. 2023.
16. Wloka, T., et al.:New water-soluble photo-initiators for two-photon polymerization based on benzylidene cyclopentanones. Journal of Photochemistry and Photobiology A: Chemistry, 2023.
17. Behrens, C., et al.:Development of a system of heparin multilayers on titanium surfaces for dual growth factor release. J Biomed Mater Res A, 2022. 110(9): p. 1599-1615.
18. Behrens, C., et al.:Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces. Int J Mol Sci, 2022. 23(14).
19. Ludolph, J., et al.:Tailored Polyelectrolyte Multilayer Systems by Variation of Polyelectrolyte Composition and EDC/NHS Cross-Linking: Controlled Drug Release vs. Drug Reservoir Capabilities and Cellular Response for Improved Osseointegration. Polymers, 2022. 14(20).
20. Schirmer, U., et al.:Tailored Polyelectrolyte Multilayer Systems by Variation of Polyelectrolyte Composition and EDC/NHS Cross-Linking: Physicochemical Characterization and In Vitro Evaluation. Nanomaterials (Basel), 2022. 12(12).
21. Delan, A., et al.:Impedimetrischer Inline-Biofilmsensor. tm - Technisches Messen, 2022. 0(0): p. 835-846.
22. Wloka, T., M. Gottschaldt, and U.S. Schubert:From light to structure – Photo initiators for radical two-photon polymerization. Chem Eur J, 2022. 28(32): p. 1-54.
23. Rothe, H., et al.:Bacterial nanocellulose: Reinforcement of compressive strength using an adapted Mobile Matrix Reservoir Technology and suitable post-modification strategies. J Mech Behav Biomed Mater, 2022. 125: p. 104978.
24. Hauptmann, N., et al.:Poly-Alanine-epsilon-Caprolacton-Methacrylate as Scaffold Material with Tuneable Biomechanical Properties for Osteochondral Implants. Int J Mol Sci, 2022. 23(6): p. 1-19.
25. Spreda, M., et al.:Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity. molecules, 2021. 26(6258).
26. Scholte, A., et al.:First Isolation and Structure Elucidation of GDNT-beta-Glu - Tetraether Lipid Fragment from Archaeal Sulfolobus Strains. ChemistryOpen, 2021. 10(9): p. 889-895.
27. Chen, L.Y., et al.:Effect of HIT Components on the Development of Breast Cancer Cells. Life (Basel), 2021. 11(8).
28. Hildebrand, G., et al.:Process Development for Additive Manufacturing of Alumina Toughened Zirconia for 3D Structures by Means of Two‐Photon Absorption Technique. ceramics, 2021. 4: p. 224-239.
29. Czich, S., et al.:Two-Photon Polymerized Poly(2-Ethyl-2-Oxazoline) Hydrogel 3D Microstructures with Tunable Mechanical Properties for Tissue Engineering. Molecules, 2020. 25(21).
30. Apte, G., et al.:Modulation of Platelet-Surface Activation: Current State and Future Perspectives. ACS Appl Bio Mater, 2020. 3(9): p. 5574-5589.
31. Wloka, T., et al.:Microfabrication of 3D-Hydrogels via two-photon polymerization of 1 poly(2-ethyl-2-oxazoline) diacrylates. European Polymer Journal, 2019. 122: p. 1-11.
32. Hauptmann, N., et al.:Biomimetic Designer Scaffolds Made of D,L-Lactide-varepsilon-Caprolactone Polymers by 2-Photon Polymerization. Tissue Eng Part B Rev, 2019. 25(3): p. 167-186.
33. Brokmann, U., et al.:Fabrication of 3D microchannels for tissue engineering in photosensitive glass using NIR femtosecond laser radiation. Biomedical Glasses, 2019. 5(1): p. 34-45.
34. Böhrnsen, F., et al.:MSC differentiation on two-photon polymerized, stiffness and BMP2 modified biological copolymers. Biomedical Materials, 2019. 14(3): p. 1-12.
35. Bartsch, H., et al.:Surface properties and biocombatibility of thick film materials used in ceramic bioreactors. Acta Biomaterialia, 2019. 5(100213).

1. Braun, F., Langner, E., Wiesmann, H., Wallmersperger, T., Kruppke, B.: Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche. Biotechnology & Bioengineering, 2026. 123(8): p. 2139–2152.
2. Braun, F., Paříková, A., Rother, S., Kantor, M., Ilyas, S.M., Bernhardt, R., Yomi, P.N., et al.: Sustainable Fabrication of Tailored Bone Substitutes: From High-Throughput Scaffold Manufacturing, Scaled-Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor. Advanced Science, 2026. p. e23846.
3. Braun, F., Appali, R., Bathel, H., Lee, P.S., Sriperumbudur, K.K., Neubert, H., van Rienen, U., et al.: Multifactorial design considerations for 3D-Printed PCL-CaCO3 bone graft scaffolds: mechanical, degradation, and electrical field-related aspects. Materials & Design, 2026. 267: p. 116324.
4. Guder, C., Bertram, P., Alt, F., Bernhardt, R., Kruppke, I., Wiesmann, H., Cherif, C., et al.: 4D degradation analysis of gelatin-modified calcium/strontium phosphate bone substitutes with µCT-flow chamber. Journal of Materials Research, 2026. 41(8): p. 1269–1285.
5. Benecke, L., Lohrberg, O., Alt, F., Müller, M.T., Cherif, C., Neunzehn, J., Kruppke, B.: Influence of Sterilization Regime on Mechanical Properties of Calcium Carbonate‐Reinforced Polycaprolactone Scaffolds for Bone Regeneration. Journal of Biomedical Materials Research Part A, 2026. 114(1): p. e70003.
6. Jalali, S., Khiabani, M.J., Kruppke, I., Heinemann, C., Lee, P.S., Wiesmann, H., Varghese, O., et al.: Dual-component nanofiber scaffolds of silica and collagen for enhanced mechanical integrity and osteogenic bioactivity. Materials & Design, 2025. 260: p. 115249.
7. Peng, X., Janicijevic, Z., Loureiro, L.R., Hoffmann, L., Lee, P.S., Cela, I., Kruppke, B., et al.: Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation. Advanced Science, 2025. 12(41): p. e08267.
8. Alt, F., Appali, R., Lee, P.S., Kruppke, B.: Polycaprolactone composites with enhanced degradation behavior and pore geometry modulated electric field distribution for improved osteogenesis. Conference presentation, 2025.
9. Khorsandi, Z., Maham, M., Mirkhani, V., Kruppke, B., Khonakdar, H.A.: Polysaccharide-based nanoparticles for 3D (bio)printing. Advances in Colloid and Interface Science, 2025. 344: p. 103595.
10. Ilyas, S.M., Jangda, S.Z., Wiesmann, H., Kruppke, B.: Template-associated crystallization of organically modified CaCO3 via dual-membrane double migration technique: impact of voltage and temperature. Discover Materials, 2025. 5(1): p. 139.
11. Itting, P.T., Kruppke, B., Hanke, T., Vijayan, V., Heiss, C., Lips, K.S.: BDNF improves the survival of mesenchymal stem cells cultured on pre-structured gelatin material containing strontium and calcium phosphates for bone regeneration. Frontiers in Bioengineering and Biotechnology, 2025. 13: p. 1596846.
12. Moghaddam, A., Sadeghinia, A., Saebi, Y., Kruppke, B., Nobre, M.A., Dawi, E., Mehrabani, D., et al.: Electrochemical Interfaces Enhanced by Silver Nanoparticles: Insights from Biosensing Research. Journal of The Electrochemical Society, 2025. 172(8): p. 087505.
13. Shaked, S.A., Weil, S., Manor, R., Aflalo, E.D., Moscovitz, S., Maman, N., Maria, R., et al.: Cuticular proteins (crusticuls) affect 3D chitin bundle nanostructure. Nanoscale, 2025. 17(22): p. 13951–13965.
14. Guder, C., Hofmann, A., Schüler, T., Sterzenbach, T., Wiesmann, H., Lorenz, K., Hannig, C., et al.: Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity. Journal of Functional Biomaterials, 2025. 16(5): p. 182.
15. Jaleh, B., Sahraei, A., Eslamipanah, M., Seifikar, F., Azizian, S., Jalali, S., Enghardt, S., et al.: Laser-assisted synthesis of metakaolin/Pd nanocomposite and its application as catalyst in wastewater remediation. Nano-Structures & Nano-Objects, 2025. 42: p. 101471.
16. Lv, G., Wiesmann, H., Kruppke, B.: How to Use the Osteoclast Identifier Software. Applied Sciences, 2025. 15(8): p. 4208.
17. Lv, G., Heinemann, C., Wiesmann, H., Kruppke, B.: Artificial Intelligence for Image-Based Identification of Osteoclasts and Assessment of Their Maturation—Using the OC\_Identifier. Applied Sciences, 2025. 15(8): p. 4159.
18. Bahrami, M., Khonakdar, H., Moghaddam, A., Mahand, S.N., Bambizi, P.E., Kruppke, B., Khonakdar, H.A.: A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives. Progress in Biophysics and Molecular Biology, 2024. 194: p. 16–33.
19. Avatefi, M., Moghadam, N.B., Asghari, S., Bakhshesh, M., Kruppke, B., Khonakdar, H.A., Alamdaran, F.S., et al.: Cellulose acetate-based electrospun nanocomposites improved by mussel-inspired polydopamine coatings and copper iodide-decorated graphene oxide: A self-disinfecting nanofibrous membrane with potential biomedical applications. Inorganic Chemistry Communications, 2024. 170(1): p. 113181.
20. Moghaddam, A., Bahrami, M., Mirzadeh, M., Khatami, M., Simorgh, S., Chimehrad, M., Kruppke, B., et al.: Recent trends in bone tissue engineering: a review of materials, methods, and structures. Biomedical Materials, 2024. 19(4): p. 042007.
21. Nabizadeh, Z., Nasrollahzadeh, M., Kruppke, B., Nasrabadi, D.: A combination of chitosan nanoparticles loaded with celecoxib and kartogenin has anti-inflammatory and chondroprotective effects: Results from an in vitro model of osteoarthritis. Heliyon, 2024. 10(10): p. e31058.
22. Khorsandi, Z., Nasrollahzadeh, M., Kruppke, B., Abbasi, A., Khonakdar, H.A.: Research progress in the preparation and application of lignin- and polysaccharide-carbon nanotubes for renewable energy conversion reactions. Chemical Engineering Journal, 2024. 488: p. 150725.
23. Schüler, T., Guder, C., Alt, F., Lorenz, K., Sterzenbach, T., Hannig, C., Wiesmann, H.P., et al.: Degradable polycaprolactone/buffer composites as pH regulating carrier materials for drug delivery and 3D printed biomaterials. Materialia, 2024. 34: p. 102087.
24. Sarani, M., Darroudi, M., Naderifar, M., Akbarizadeh, M.R., Nobre, M.A., Kruppke, B., Khonakdar, H.A., et al.: Biosynthesis of ZnO, Bi2O3 and ZnO−Bi2O3 bimetallic nanoparticles and their cytotoxic and antibacterial effects. ChemistryOpen, 2024. 13(4): p. e202300176.
25. Jalali, S., Kruppke, I., Enghardt, S., Wiesmann, H., Kruppke, B.: Silica Nanofibers with Enhanced Wettability and Mechanical Strength for Bone Tissue Engineering: Electrospinning without Polymer Carrier and Subsequent Heat Treatment. Macromolecular Materials and Engineering, 2024. 309(1): p. 2300169.
26. Neunzehn, J., Alt, F., Wiesmann, H.P., Kruppke, B.: Osteogenic stimulation of osteoprogenitors by putamen ovi peptides and hyaluronic acid. Head & Face Medicine, 2023. 19(1): p. 19–34.
27. Gharoubi, H., Nasrollahzadeh, M., Khorsandi, Z., Nobre, M.A., Choi, S., Kruppke, B., Ali Khonakdar, H.: Grafting Cu(II)-5-amino-1H-tetrazole complex on magnetic graphene oxide as an efficient magnetically recoverable catalyst for the synthesis of N-benzyl-N-aryl-5-amino-1H-tetrazoles. Inorganic Chemistry Communications, 2023. 153: p. 110653.
28. Hajibeygi, M., Soltani, F., Shabanian, M., Maleki, M., Khonakdar, H.A., Kruppke, B.: Plasticized polyvinyl chloride/melamine-cyanurate modified Mg(OH)2@bentonite nanocomposites; mechanical, thermal, and flame retardant properties. Journal of Vinyl and Additive Technology, 2023. 30(1): p. 114–129.
29. Heinemann, C., Buchner, F., Lee, P.S., Bernhardt, A., Kruppke, B., Wiesmann, H., Hintze, V.: Effects of Gamma Irradiation and Supercritical Carbon Dioxide Sterilization on Methacrylated Gelatin/Hyaluronan Hydrogels. Journal of Functional Biomaterials, 2023. 14(6): p. 317.
30. Safari, M., Moghaddam, A., Salehi Moghaddam, A., Absalan, M., Kruppke, B., Ruckdäschel, H., Khonakdar, H.A.: Carbon-based biosensors from graphene family to carbon dots: A viewpoint in cancer detection. Talanta, 2023. 258: p. 124399.
31. Nemati Mahand, S., Niknami, N., Moghaddam, A., Nemati Mahand, S., Salehi Moghaddam, A., Arjmand, M., Alt, F., et al.: Application of stem cells, growth factors, small molecules, and biological macromolecules on nerve regeneration: a review and future direction. International Journal of Polymeric Materials and Polymeric Biomaterials, 2023. 73(9): p. 817–849.
32. Hajibeygi, M., Javadi-gharyesafa, A., Shabanian, M., Khonakdar, H.A., Kruppke, B., Meier-Haack, J.: Improving the properties of rigid polyvinyl chloride with surface-treated Mg(OH)(2) nanoparticles and ester-functionalized organic additive. Journal of Thermal Analysis and Calorimetry, 2023. 148(10): p. 4059–4073.
33. Nasrollahzadeh, M., Motahharifar, N., Pakzad, K., Khorsandi, Z., Baran, T., Wang, J., Kruppke, B., et al.: Synthesis of a magnetic polystyrene-supported Cu(II)-containing heterocyclic complex as a magnetically separable and reusable catalyst for the preparation of N-sulfonyl-N-aryl tetrazoles. Scientific Reports, 2023. 13: p. 3214.
34. Mahand, S., Jahanmardi, R., Kruppke, B., Khonakdar, H.: Sciatic nerve injury regeneration in adult male rats using gelatin methacrylate (GelMA)/poly(2-ethy-2-oxazoline) (PEtOx) hydrogel containing 4-aminopyridine (4-AP). Journal of Biomedical Materials Research Part A, 2023. 111(8): p. 1243–1252.
35. Fakhri, V., Jafari, A., Zeraatkar, A., Rahimi, M., Hadian, H., Nouranian, S., Kruppke, B., et al.: Introducing photo-crosslinked bio-nanocomposites based on polyvinylidene fluoride/poly(glycerol azelaic acid)-g-glycidyl methacrylate for bone tissue engineering. Journal of Materials Chemistry B, 2023. 11(2): p. 452–470.
36. Pourmasoumi, P., Moghaddam, A., Nemati Mahand, S., Heidari, F., Salehi Moghaddam, Z., Arjmand, M., Kühnert, I., et al.: A review on the recent progress, opportunities, and challenges of 4D printing and bioprinting in regenerative medicine. Journal of Biomaterials Science, Polymer Edition, 2023. 34(1): p. 108–146.
37. Alt, F., Heinemann, C., Kruppke, B.: Class I Biocompatible DLP-Printed Acrylate Impairs Adhesion and Proliferation of Human Mesenchymal Stromal Cells in Indirect Cytotoxicity Assay. BioMed Research International, 2023. p. 2–5.
38. Kruppke, B., Apelt, S., Hartwig, C.E., Koch, A., Mai, J., Schumann, A.L., Ulbricht, T.J., et al.: Das Kompetenzatelier als agiles Lehrformat: Biomechanik-Projektarbeit bis zum Prototyp. Lessons Learned, 2022. 2(2): p. 1–10.
39. Nasri, A., Jaleh, B., Shabanlou, E., Nasrollahzadeh, M., Ali Khonakdar, H., Kruppke, B.: Ionic liquid-based (nano)catalysts for hydrogen generation and storage. Journal of Molecular Liquids, 2022. 365: p. 120142.
40. Nemati Mahand, S., Aliakbarzadeh, S., Moghaddam, A., Salehi Moghaddam, A., Kruppke, B., Nasrollahzadeh, M., Khonakdar, H.A.: Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications. European Polymer Journal, 2022. 178: p. 111484.
41. Kruppke, B.: Förderung von Selbst- und Methodenkompetenz im digitalen Biomechanikpraktikum. Lessons Learned, 2022. 2(1): p. 1–8.
42. Elashry, M.I., Baulig, N., Wagner, A., Klymiuk, M.C., Kruppke, B., Hanke, T., Wenisch, S., et al.: Combined macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose-derived mesenchymal stem cells. Stem Cell Research & Therapy, 2021. 12(1): p. 116.
43. Akhmedov, S., Afanasyev, S., Trusova, M., Postnikov, P., Rogovskaya, Y., Grakova, E., Kopeva, K., et al.: Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques. Biomedicines, 2021. 9(7): p. 802.
44. Kruppke, B., Heinemann, C., Gebert, A., Rohnke, M., Weiß, M., Henß, A., Wiesmann, H., et al.: Strontium substitution of gelatin modified calcium hydrogen phosphates as porous hard tissue substitutes. Journal of Biomedical Materials Research Part A, 2021. 109(5): p. 722–732.
45. Kruppke, B.: Digital Experiments in Higher Education-A "How to" and "How It Went" for an Interactive Experiment Lecture on Dental Materials. Education Sciences : open access journal, 2021. 11(4): p. 190.
46. Rößler, S., Brückner, A., Kruppke, I., Wiesmann, H.P., Hanke, T., Kruppke, B.: 3D plotting of silica/collagen xerogel granules in an alginate matrix for tissue-engineered bone implants. Materials, 2021. 14(4): p. 1–12.
47. Heinemann, C., Adam, J., Kruppke, B., Hintze, V., Wiesmann, H., Hanke, T.: How to Get Them off?-Assessment of Innovative Techniques for Generation and Detachment of Mature Osteoclasts for Biomaterial Resorption Studies. International Journal of Molecular Sciences, 2021. 22(3): p. 1–13.
48. Kruppke, B.: Der Mix macht's – Asynchron , synchron , inverted von der Folienvertonung bis zum Experiment. Lessons Learned, 2021. 1: p. 1&2.
49. Opitz, J., Porstmann, V., Schreiber, L., Schmalfuß, T., Lehmann, A., Naumann, S., Schallert, R., et al.: Optical Coherence Tomography as Monitoring Technology for the Additive Manufacturing of Future Biomedical Parts. *Handbook of Nondestructive Evaluation 4.0*. Springer, 2021. p. 1–23.
50. Rößler, S., Unbehau, R., Gemming, T., Kruppke, B., Wiesmann, H.P., Hanke, T.: Calcite incorporated in silica/collagen xerogels mediates calcium release and enhances osteoblast proliferation and differentiation. Scientific Reports, 2020. 10(118): p. 118.
51. Böhnke, P.R.C., Kruppke, I., Hoffmann, D., Richter, M., Häntzsche, E., Gereke, T., Kruppke, B., et al.: Matrix Decomposition of Carbon-Fiber-Reinforced Plastics via the Activation of Semiconductors. Materials, 2020. 13(15): p. 3267.
52. Kruppke, B., Farack, J., Weil, S., Aflalo, E.D., Poláková, D., Sagi, A., Hanke, T.: Crayfish hemocyanin on chitin bone substitute scaffolds promotes the proliferation and osteogenic differentiation of human mesenchymal stem cells. Journal of Biomedical Materials Research - Part A, 2020. 108(3): p. 694–708.
53. Thomas, J., Worch, H., Kruppke, B., Gemming, T.: Contribution to understand the biomineralization of bones. Journal of Bone and Mineral Metabolism, 2020. p. 456–468.
54. Kruppke, B., Ray, S., Alt, V., Rohnke, M., Kern, C., Kampschulte, M., Heinemann, C., et al.: Gelatin-Modified Calcium/Strontium Hydrogen Phosphates Stimulate Bone Regeneration in Osteoblast/Osteoclast Co-Culture and in Osteoporotic Rat Femur Defects—In Vitro to In Vivo Translation. Molecules, 2020. 21: p. 5103.
55. Kruppke, B., Heinemann, C., Farack, J., Weil, S., Aflalo, E.D., Sagi, A., Hanke, T.: Hemocyanin Modification of Chitosan Scaffolds with Calcium Phosphate Phases Increase the Osteoblast / Osteoclast Activity Ratio — A Co-Culture Study. Molecules, 2020. 19: p. 4580.
56. Kruppke, B., Weiß, J., Rößler, S., Heinemann, C., Hanke, T.: Novel degradation flow‐through chamber for in vitro biomaterial characterization. Journal of biomedical materials research, 2020. p. 3124–3133.
57. Heinemann, C., Brünler, R., Kreschel, C., Kruppke, B., Bernhardt, R., Aibibu, D., Cherif, C., et al.: Bioinspired calcium phosphate mineralization on net-shape-nonwoven chitosan scaffolds stimulates human bone marrow stromal cell differentiation. Biomedical Materials, 2019. 14(4): p. 045017.
58. Kruppke, B., Wagner, A., Rohnke, M., Heinemann, C., Kreschel, C., Gebert, A., Wiesmann, H., et al.: Biomaterial based treatment of osteoclastic/osteoblastic cell imbalance – Gelatin-modified calcium/strontium phosphates. Materials Science and Engineering: C, 2019. p. 104.
59. Heinemann, C., Heinemann, S., Rößler, S., Kruppke, B., Wiesmann, H., Hanke, T.: Organically modified hydroxyapatite (ormoHAP) nanospheres stimulate the differentiation of osteoblast and osteoclast precursors: a co-culture study. Biomedical Materials, 2019. 3: p. 1487–1495.
60. Zwahr, C., Welle, A., Weingärtner, T., Heinemann, C., Kruppke, B., Gulow, N., große Holthaus, M., et al.: Ultrashort Pulsed Laser Surface Patterning of Titanium to Improve Osseointegration of Dental Implants. Advanced Engineering Materials, 2019. 21(12): p. 1900639.
61. Rößler, S., Heinemann, C., Kruppke, B., Wagner, A.S., Wenisch, S., Wiesmann, H.P., Hanke, T.: Manipulation of osteoclastogenesis: Bioactive multiphasic silica/collagen composites and their effects of surface and degradation products. Materials Science and Engineering: C, 2018. 93: p. 265–276.
62. Kruppke, B., Hose, D., Schnettler, R., Seckinger, A., Rößler, S., Hanke, T., Heinemann, S.: Drug Release as a function of bioactivity, incubation regime, liquid, and initial load: Release of bortezomib from calcium phosphate‐containing silica/collagen xerogels. Journal of biomedical materials research, 2018. 106: p. 1165–1173.
63. Kruppke, B., Heinemann, C., Wagner, A.S., Farack, J., Wenisch, S., Wiesmann, H., Hanke, T.: Strontium ions promote in vitro human bone marrow stromal cell proliferation and differentiation in calcium-lacking media. Development, Growth & Differentiation, 2018. 61(2): p. 166–175.
64. Kruppke, B.: Biomimetische Materialentwicklung für den Knochenersatz. Dissertation, 2017. 159 p.
65. Kruppke, B., Heinemann, C., Keroué, A., Thomas, J., Rößler, S., Wiesmann, H., Gemming, T., et al.: Calcite and Hydroxyapatite Gelatin Composites as Bone Substitution Material Made by Double Migration Technique.. Crystal Growth & Design, 2017. 17: p. 738–745.
66. Wagner, A., Glenske, K., Henß, A., Kruppke, B., Rößler, S., Hanke, T., Moritz, A., et al.: Cell behavior of human mesenchymal stromal cells in response to silica/collagen based xerogels and calcium deficient culture conditions. Biomedical Materials, 2017. 4: p. 1–12.
67. Kruppke, B., Farack, J., Sommer, F., Weil, S., Aflalo, E.D., Wiesmann, H., Sagi, A., et al.: In Situ Crosslinking of Highly Porous Chitosan Scaffolds for Bone Regeneration: Production Parameters and In Vitro Characterization. Macromolecular Materials and Engineering, 2017. 10: p. 302.
68. Heinemann, C., Heinemann, S., Kruppke, B., Worch, H., Thomas, J., Wiesmann, H.P., Hanke, T.: Electric field-assisted formation of organically modified hydroxyapatite (ormoHAP) spheres in carboxymethylated gelatin gels. Acta Biomaterialia, 2016. 44: p. 135–143.
69. Kluemper, C., Neunzehn, J., Wegmann, U., Kruppke, B., Joos, U., Wiesmann, H.P.: Development and evaluation of an internet-based blended-learning module in biomedicine for university applicants - Education as a challenge for the future -. Head & Face Medicine, 2016. 12(1): p. 13.
70. Kruppke, B., Farack, J., Wagner, A., Beckmann, S., Heinemann, C., Glenske, K., Roessler, S., et al.: Gelatine modified monetite as a bone substitute material: An in vitro assessment of bone biocompatibility. Acta Biomaterialia, 2016. 32: p. 275–285.
71. Glenske, K., Wagner, A., Hanke, T., Cavalcanti-Adam, E.A., Heinemann, S., Heinemann, C., Kruppke, B., et al.: Bioactivity of xerogels as modulators of osteoclastogenesis mediated by connexin 43. Biomaterials, 2014. 5: p. 1487–1495.
72. Kruppke, B.: Einfluss verschiedener Calciumphosphatphasen auf die Bioaktivität, Biokompatibilität und biaxiale Festigkeit von Silikat/Kollagen-Xerogelen. Diplomarbeit, 2012. 98 p.

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