Fachbereich Analysenmesstechnik
Der fortschreitende Grad der Automation und Miniaturisierung in der Bio- und Medizintechnik erfordert den Einsatz moderner und vor allem schneller Messmittel zur kontinuierlichen Gewinnung von Prozessdaten. Im Fachbereich Analysemesstechnik werden innovative Werkzeuge zur messtechnischen Überwachung von Prozessen in den angewandten Lebenswissenschaften (Life Sciences) erforscht.
Schwerpunkt der Forschung: Impedanzspektroskopie
- Schnelle Charakterisierung biologischer Materialien mittels breitbandiger elektrischer Impedanzspektroskopie (EIS) im Frequenzbereich von einigen mHz bis zu 100 GHz. Schnelle Methodenmit Kleinsignalanregung dienen dabei der Erfassung von schnell veränderlichen oder elektrisch nichtlinearen Eigenschaften (zeitvariante und nichtlineare Objekte).
- Die Messung mittels Impedanzspektroskopie beruht auf der Wechselwirkung von beweglichen Ladungsträgern und dem elektrischen Feld z.B. in biologischen Materialien oder Ionen und Elektronen an der Grenz- bzw. Oberfläche zwischen Leitern und Elektrolyten (Elektroden).
- Die elektrischen Eigenschaften werden frequenzabhängig erfasst (Spektroskopie), wodurch unterschiedliche für die Charakterisierung von Materialien auftretende Polarisationsmechanismen untersucht werden können.
- Die Bioimpedanz kann zur schnellen und minimal- bzw. nichtinvasiven Charakterisierung biologischer Objekte eingesetzt werden.
- Realisierung von In- und Online-Analytik für Applikationen in der Bio-, Medizin- Lebensmittel- und Umwelttechnik.
- Partner für KMU’s bei der Entwicklung von Messsystemen.
- Wir bieten problemangepasste Komplettlösungen für die Forschung und Industrie.
- Projekte
Projekt Fördermittelgeber Laufzeit Frequenzsensitive Mechanotransduktion entlang der Mikrotubuli als möglicher Auslöser für die Chromatidentrennung (MeTraChro) TMWLLR 12.25 - 11.28 Development of multifunctional nanostructured surfaces for the improvement of blood-contracting devices (Nanostructures) DFG 01.26 - 12.28 Klassifizierung von Krankheitsbildern bei Milchkühen durch Auswertung des dynamischen Trittmusters (KuhMa) BMWE / AiF 07.25 - 12.27 Einzelemitteranalyse an Me:DNA-Clustern zur Aufklärung des Fluoreszenzmechanismus (FluoDNA) TMWWDG 12.24 - 11.27 Zerstörungsfreie Bestimmung der Vitalität von Embryonen der Hybridlärche und Online-Monitoring der Wurzelbildung und des Wachstums von Hybridlärchen und Arzneipflanzen auf Basis impedanzspektroskopischer Messmethoden (RhizoEIS) BMEL / FNR 09.24 - 08.27 Entwicklung eines nicht-invasiven Multisensors zur Analyse fluidischer Stoffströme für pharmazeutische, biotechnologische und medizinische Anwendungen (ENIKOS) BMWi / AiF 10.23 - 12.25 DNA-stabilisierte Metallquantencluster als Emitter verschränkter Photonen (QC4EP) BMBF / VDI 09.23 - 08.26 Electrical impedance tomography based on relaxation measurements in time domain (Relax-EIT) DFG 02.24 - 01.27 Orthogonales Multisensorsystem zur Online-Überwachung der initialen bakteriellen Adhäsion an Grenzflächen sowie der Dynamik des sich daran anschließenden Wachstums des Biofilms (OrthoBio) DFG 10.22 - 03.26 Covid-19 Speke Proteins Form Antigenic Complexes with Platelet Factor 4 that Trigger Production of Pathogenic Antibodies: A New Mechanism of Autoimmunity Trombocytopenia (Covid-19 Spike-PF4) DFG 03.22 - 12.25 13. International Confernce on Bioelectromagnetism (ICBEM 2021) DFG 01.21 - 05.21 Rein-Wasser - Reinigung und Überwachung von Trinkwasser durch innovative Oxidationsprozesse und Absorbermaterialien
Teilprojekt:
Entwicklung, Charakterisierung und Optimierung elektrodenbasierter Sensorstreifen für anorganische Schadstoffe und organische Spurenstoffe, die mit nur einem Analysegerät ausgewertet werden können (Rein-Wasser)|BMWi / AiF|08.20 - 03.23Entwicklung einer hochsensitiven Lauffläche zur Früherkennung von Klauenkrankheiten bei Rindern (TreFKkla) BLE 10.20 - 12.23 Erforschung und Entwicklung eines energieeffizienten Breitband-Impedanz-Chips zur Echtzeit-Zellkulturüberwachung (BICCell) BMWi / AiF / Dechema 07.20 - 12.23 Innovationsgutschein für die Beantragung eines AiF-ZIM-Projektes:
Entwicklung eines biomimetischen Sensors für den Nachweis von Protein-Bio-markern (Protein-Biomarker)|TMWWDG|10.19 - 04.21Entwicklung eines RFID-basierenden Sensorchip zur drahtlosen Erfassung von Impedanzspektren im Bereich von Hertz bis Megahertz (RFID-EIS-Tag) BMWi / AiF 09.19 - 04.22 Geothermisches Monitoring für den Einbau und Betrieb mit integriertem Verbrauchsmonitoring zur individuellen Optimierung der Wärmepumpe
Weiterführung von 04/15 (GeoMo)|BMWi / PT Jülich|01.19 - 12.21Aufschlusserweiterungen von Schlämmen zur sinifikanten Steigerung des Faulgasertrages zur Verringerung der Klärschlammmenge sowie Belastung durch endikrine Substanzen und zur Verbesserung der Verfahrensstabilität (PlasmaCrack) BMWi / VDI-VDE (ZIM) 01.19 - 12.22 Characterization of Platelet factor 4-Polyanion Complexes and Corresponding Pathogenic Antibodies (PF4-Polyanion) DFG 11.19 - 03.22 Innovationsgutschein für die Beantragung eines IraSME-Projektes: Mulsisensorplattform zur Untersuchung und Überwachung der Biofilmbildung (Innovationsgutschein Antibiotika) TMWWDG 05.18 - 10.18 Parameter zur Erfassung der Textur von Zuckerrüben zur Verbesserung der Effizienz bei Lagerung und Verarbeitung, Hochfrequenz-Sensorentwicklung und applikationsuntersuchungen für SUB (Zuckerrübe) BMWi / AiF 01.18 - 03.21 Innovationsgutschein für die Beantragung eines IGF-Projektes mit dem Titel:"Multisensorplattform zur Untersuchung und Überwachung der Biofilmbildung (Multisensor Biofilm) TMWWDG 02.17 - 10.17 Entwicklung einer innovativen impedimetrischen Messmethode zur vollautomatisierten Bestimmung von Medikamentenrückständen in Klärwerksabwässern mit Hilfe von Aptameren (Aptamaster) BMWi / AiF 09.16 - 08.19 Impedanzspektroskopische Analytik - schnell und hochparallel (Forschergruppe) TMWWDG 11.16 - 10.18 - Publikationen Analysenmesstechnik
- Mytiliniou, M., et al.:Effect of G(4)C(2)repeat expansions on the motion of lysosomes inside neurites. Phys Biol, 2026. 23(2).
- Wondergem, J.A.J., et al.:Long-range topotaxis as a result of supercellular topographic anisotropy during chemotaxis. Physical Review Research, 2026. 8(2): p. 023234.
- Zheng, J., et al.:A QCM-Based Biosensor to Detect HIT-like Antibodies: Differentiating KKO from RTO via FcgammaRIIA Interactions. Anal Chem, 2025. 97(31): p. 16851-16858.
- Gansauge, C., D. Echtermeyer, and D. Frense:Simulation of Electrical Biofilm Impedance to Determine the Sensitivity of Electrode Geometries. Chemosensors, 2024. 12(1): p. 14.
- Momeni, M., et al.:A Quasi-3-D Impedance Measurement Using the Square Wave Method With Parallactic Excitation for Detection of Biofilm Growth. IEEE Transactions on Instrumentation and Measurement, 2024. 73: p. 1-11.
- Oberhaus, F.V.:Carbonyl compounds and inorganic Brønsted acids as catalysts for electropolymerization of conductive polymers. Electrochimica Acta, 2023. 449: p. 142237.
- van Steijn, L., et al.:Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments. Biophys J, 2023. 122(13): p. 2791-2807.
- Binder, P. and F.V. Oberhaus:Straightforward fabrication of electrochemical aptasensors with outstanding antifouling performance. Anal Chim Acta, 2023. 1274: p. 341575.
- Zeußel, L., et al.:Visible-Light-Assisted Donor–Acceptor-Stenhouse-Adduct-Based Reversible Photoswitching on a Laser-Structurable OrmoComp Substrate. ACS Applied Polymer Materials, 2023. 5(10): p. 8631-8640.
- Mytiliniou, M., et al.:Impact of neurite alignment on organelle motion. J R Soc Interface, 2022. 19(187): p. 20210617.
- Oberhaus, F.V. and D. Frense:Catalysing electropolymerization: High-quality polythiophene films for electrochemical sensors by the utilization of fluorine based Lewis acid catalysts. Electrochimica Acta, 2022. 402: p. 139536.
- Tong, C., et al.:Spatial and Temporal Modulation of Cell Instructive Cues in a Filamentous Supramolecular Biomaterial. ACS Applied Materials & Interfaces, 2022. 14(15): p. 17042-17054.
- Zaikou, Y., et al.:Algorithms for Reconstruction of Impedance Spectra from Non-uniformly Sampled Step Responses. J Electr Bioimpedance, 2022. 13(1): p. 143-149.
- Hasselmann, S., et al.:Tailored nanotopography of photocurable composites for control of cell migration. RSC Adv, 2021. 11(8): p. 4286-4296.
- Poßner, L., et al.: A four-point measurement probe for brain tissue conductivity and permittivity characterization. in International Journal of Bioelectromagnetism. 2021.
- Liu, T., et al.:Squaramide-Based Supramolecular Materials Drive HepG2 Spheroid Differentiation. Adv Healthc Mater, 2021. 10(11): p. e2001903.
- Emmert, M., et al.:Modulation of Mammalian Cell Behavior by Nanoporous Glass. Adv Biol (Weinh), 2021. 5(7): p. e2000570.
- Oberhaus, F.V. and D. Frense:Fast, simple, and gentle method for removal of polythiophene and other conductive polymer films from gold electrodes. Journal of Electroanalytical Chemistry, 2021. 895: p. 115466.
- Zhou, X.Q., et al.:Intracellular Dynamic Assembly of Deep-Red Emitting Supramolecular Nanostructures Based on the Pt...Pt Metallophilic Interaction. Adv Mater, 2021. 33(37): p. e2008613.
- Gansauge, C., K. Schieke, and U. Pliquett.: ECIS 10.000 Channels - Feasibility Study on Biofilm Growth". in International Journal of Bioelectromagnetism. 2021.
- Hasselmann, S., et al.:Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel. Mater Horiz, 2021. 8(12): p. 3334-3344.
- Zaikou, Y., T. Nacke, and U. Pliquett.: High Frequency Impedance Spectroscopy for Biotechnological Applications. in 2021 International Workshop on Impedance Spectroscopy (IWIS). 2021.
- Mytiliniou, M., et al.:Effect of G4C2 Repeat Expansions on the Motion of Lysosomes Inside Neurites. bioRxiv, 2021: p. 2021.10.29.466472.
- Pliquett, U.:Fast Electrical Characterization with Low Hardware Requirement. J Electr Bioimpedance, 2020. 11(1): p. 1-3.
- Poßner, L., et al.:In situ impedance measurements on postmortem porcine brain. Current Directions in Biomedical Engineering, 2020. 6(3): p. 143-146.
- Oberhaus, F.V., D. Frense, and D. Beckmann:Immobilization Techniques for Aptamers on Gold Electrodes for the Electrochemical Detection of Proteins: A Review. Biosensors (Basel), 2020. 10(5).
- Pliquett, U., et al.: Impedimetric Sensor Using Electric Relaxation. in International Journal of Bioelectromagnetism. 2020.
- Nguyen, T.A., et al.:Multichannel Cell Detection in Microcompartments by Means of True Parallel Measurements using the Solartron S-1260. J Electr Bioimpedance, 2020. 11(1): p. 49-56.
- Nacke, T., et al.:Entwicklung einer miniaturisierten absenkbaren Radarsonde zur Qualitätsüberwachung der Hinterfüllung von oberflächennahen Erdwärmesonden. Geothermische Energie, Fachzeitschrift für geothermische Forschung und Anwendung in Deutschland, Österreich und Schweiz, 2020. 97.
- Pliquett, U., et al.: Body Impedance Spectroscopy Based on Electrical Relaxation Behavior: Advantages and Challenges. in International Journal of Bioelectromagnetism. 2019.
- Gansauge, C., et al.: Fast Bio-Impedence Analysis using Electrical Relaxation. in International Journal of Bioelectromagnetism. 2019.
- Li, Y.J., et al.:Non-linearity and dynamics of low-voltage electrowetting and dewetting. Phys Chem Chem Phys, 2019. 21(33): p. 18290-18299.
- Publikationen Prof. Dr. Doris Heinrich
- Schröder, S., Rothe, H., Rehbein-Bode, E., Heinrich, D., Teusch, N., & Brandes, N.: Novel dermis niche equivalent based on a 3D-structure fabricated by 2-photon polymerization. Biomaterials and Biosystems, 2026. 23: p. 100143.
- Küstner, M.-J., Marx, C., beim Graben, P., Rodrigues, S., Hampl, J., Weise, F., Gebinoga, M., Kaysan, L., Klett, M., Brauer, D., Schlingloff, G., Heinrich, D., Schroeder, I.S., & Schober, A.: Biotechnical multiscale engineering of scaffolds for stem cell and organoid research. Small, 2026. 22(12): p. e04070.
- Mytiliniou, M., Wondergem, J.A.J., Feliksik, M., Schmidt, T., Fuhs, T., & Heinrich, D.: Effect of G4C2 repeat expansions on the motion of lysosomes inside neurites. Physical Biology, 2026. 23(2): p. 026008.
- Tong, C., Chen, Y., Janssen, M.L., Sariol, I., Wondergem, J.A.J., van den Brink, M., Özel, M., Nelissen, R.G.H.H., Meulenbelt, I., Heinrich, D., Ramos, Y.F.M., & Kieltyka, R.E.: Supramolecular engineering of fluid pressure in filamentous hybrid double network hydrogels for 3D chondrocyte culture. Advanced Healthcare Materials, 2026. 15(21): p. e05238.
- Mohamadian Namaqi, M., Moll, F., Römer, R., Grodrian, A., Heinrich, D., & Lemke, K.: Advanced mounting technique for improved imaging and analysis of embedded spheroids and migrating cells in light sheet fluorescence microscopy. Advanced Materials Technologies, 2026. 11(8): p. e01551.
- Sokoliuk, D., Bouhaya, R., Haeger, P., Godthardt, K., Fetting, D., Spiecker, L., Spiecker, H., Rockenbach, A., Rothe, H., Liefeith, K., & Heinrich, D.: Synergistic combination of additive one- and two-photon polymerization printing methods to fabricate 3D microstructured perfusable angiogenesis-on-a-chip systems. Engineering in Life Sciences, 2026. 26(1): p. e70059.
- Abeln, D.: Entwicklung neuartiger Chip-basierter Gefäßsysteme: Herstellungsverfahren mit Ein- und Zweiphotonen-Polymerisationsdruck, Extrusionsdruck mit Hydrogelen und PDMS-Weichlithographie. Technische Universität Ilmenau, Ilmenau, 2026.
- Börke, J.M., Rothe, H., Dobler, L., Frühauf, W., Bittrich, E., Heinrich, D., & Liefeith, K.: Model system for investigating glycocalyx-relevant hydration phenomena. ACS Applied Materials & Interfaces, 2026. 18(15): p. 22537–22551.
- Soter, M., Madkatte, D., Heinrich, D., & Nguyen, T.-H.: Geometry-dependent pitch variation controls platelet adhesion on FluidFM-fabricated residual-layer-free micro/nanostructures. ACS Omega, 2026. 11(15): p. 22753–22765.
- Apte, G., Soter, M., Madkatte, D., Heinrich, D., & Nguyen, T.-H.: Agarose micro/nanostructured surfaces: a step toward an innovative solution for platelet storage bags. Advanced Functional Materials, 2025. 35(4): p. 2414096.
- Saupe, M., Wiedemeier, S., Moll, F., Köhler, J.M., Heinrich, D., & Lemke, K.: Droplet-based cell viability assay for analysis of spheroid formation, proliferation and high-resolution IC₅₀ profiling. Lab on a Chip, 2025. 25(23): p. 6138–6156.
- Gonzalez-Serrano, M.S., Chen, L.-Y., Desai, H., Ho, T.H., Heinrich, D., Trinh, T.T., & Nguyen, T.-H.: Molecular insights into the interaction between CD147 and the SARS-CoV-2 spike protein. ACS Omega, 2025. 10(32): p. 36025–36040.
- Chen, L.-Y., Schirmer, U., Zipfel, P.F., Heinrich, D., & Nguyen, T.-H.: Optimized cell-based platform for platelet-free detection of heparin-induced thrombocytopenia antibodies. Advanced Biology, 2025. 9(10): p. e00079.
- Abedin, S., Reich, P., Bartsch, H., & Pezoldt, J.: TiN nanogap electrodes for DNA nanoelectronics and computing: fabrication and characterization. MikroSystemTechnik Kongress 2025, 27.–29. Oktober 2025, Duisburg, 2025: p. 143.
- Zheng, J., El Harakeh, M.D., Seo, D., Cabral, H., Nguyen, T.-H., Yagi, S., Kim, J., & Sugihara, K.: A QCM-based biosensor to detect HIT-like antibodies: differentiating KKO from RTO via FcγRIIA interactions. Analytical Chemistry, 2025. 97(31): p. 16851–16858.
- Soter, M., Apte, G., Madkatte, D., & Nguyen, T.-H.: Insights into the writing process of the mask-free nanoprinting fluid force microscopy technology. Measurement Science and Technology, 2024. 35(8): p. 085605.
- Nguyen, T.-H., Chen, L.-Y., Khan, N.Z., Lindenbauer, A., Bui, V.-C., Zipfel, P.F., & Heinrich, D.: The binding of the SARS-CoV-2 spike protein to platelet factor 4: a proposed mechanism for the generation of pathogenic antibodies. Biomolecules, 2024. 14(3): p. 245.
- Bui, V.-C., & Nguyen, T.-H.: Mechanics of leukemic T-cell. Journal of Molecular Recognition, 2023. 36(7): p. e3019. [10th AFM BioMed Conference, Nagoya-Okazaki, 29 August–2 September 2022].
- van Steijn, L., Wondergem, J.A.J., Schakenraad, K., Heinrich, D., & Merks, R.M.H.: Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments. Biophysical Journal, 2023. 122(13): p. 2791–2807.
- Zeußel, L., Schober, A., Ullmann, F., Krischok, S., Heinrich, D., & Singh, S.: Visible-light-assisted donor-acceptor-Stenhouse-adduct-based reversible photoswitching on a laser-structurable OrmoComp substrate. ACS Applied Polymer Materials, 2023. 5(10): p. 8631–8640.
- Soter, M., Apte, G., Madkatte, D., & Nguyen, T.-H.: Insights into the writing process of the mask-free nanoprinting fluid force microscopy technology. Engineering for a Changing World: 60th ISC, Ilmenau Scientific Colloquium, Technische Universität Ilmenau, September 4–8, 2023. 2023: Proceedings: p. 1.2.118.
- Nguyen, T.-H., Wang, H., Chen, L.-Y., Echtermeyer, D., & Pliquett, U.: Modulating SARS-CoV-2 spike protein reactivity through moderate electric fields: a pathway to innovative therapies. ACS Omega, 2023. 8(48): p. 45952–45960.
- Chen, L.-Y., Schirmer, U., Widder, M., Gruel, Y., Rollin, J., Zipfel, P.F., & Nguyen, T.-H.: Breast cancer cell-based ELISA: a potential material for better detection of heparin-induced thrombocytopenia antibodies. Journal of Materials Chemistry B, 2022. 10(38): p. 7708–7716.
- Tong, C., Wondergem, J.A.J., van den Brink, M., Kwakernaak, M.C., Chen, Y., Hendrix, M.M.R.M., Voets, I.K., Danen, E.H.J., Le Dévédec, S., Heinrich, D., & Kieltyka, R.E.: Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial. ACS Applied Materials & Interfaces, 2022. 14(15): p. 17042–17054.
- Mytiliniou, M., Wondergem, J.A.J., Schmidt, T., & Heinrich, D.: Impact of neurite alignment on organelle motion. Journal of the Royal Society Interface, 2022. 19(187): p. 20210617.
- Chen, L.-Y., Khan, N., Lindenbauer, A., & Nguyen, T.-H.: When will fondaparinux induce thrombocytopenia? Bioconjugate Chemistry, 2022. 33(8): p. 1574–1583.
- Schemberg, J., El Abbassi, A., Lindenbauer, A., Chen, L.-Y., Grodrian, A., Nakos, X., Apte, G., Khan, N., Kraupner, A., Nguyen, T.-H., & Gastrock, G.: Synthesis of biocompatible superparamagnetic iron oxide nanoparticles (SPION) under different microfluidic regimes. ACS Applied Materials & Interfaces, 2022. 14(42): p. 48011–48028.
- Apte, G., Hirtz, M.M., & Nguyen, T.-H.: FluidFM-based fabrication of nanopatterns: promising surfaces for platelet storage application. ACS Applied Materials & Interfaces, 2022. 14(21): p. 24133–24143.
- Berganza, E., Apte, G., Vasantham, S.K., Nguyen, T.-H., & Hirtz, M.: Integration of biofunctional molecules into 3D-printed polymeric micro-/nanostructures. Polymers, 2022. 14(7): p. 1327.
- Khan, N.Z., Martin, D., Pliquett, U., Zaikou, Y., Nacke, T., Heinrich, D., Köhler, M., & Nguyen, T.-H.: High-frequency contactless sensor for the detection of heparin-induced thrombocytopenia antibodies via platelet aggregation. International Journal of Molecular Sciences, 2022. 23(22): p. 14395.
- Khan, N.Z., Chen, L.-Y., Lindenbauer, A., Pliquett, U., Rothe, H., & Nguyen, T.-H.: Label-free detection and characterization of heparin-induced thrombocytopenia (HIT)-like antibodies. ACS Omega, 2021. 6(40): p. 25926–25939.
- Liu, T., van den Berk, L., Wondergem, J.A.J., Tong, C., Kwakernaak, M.C., ter Braak, B., Heinrich, D., van de Water, B., & Kieltyka, R.E.: Squaramide-based supramolecular materials drive HepG2 spheroid differentiation. Advanced Healthcare Materials, 2021. 10(11): p. 2001903.
- Emmert, M., Somorowsky, F., Ebert, J., Görick, D., Heyn, A., Rosenberger, E., Wahl, M., & Heinrich, D.: Modulation of mammalian cell behavior by nanoporous glass. Advanced Biology, 2021. 5(7): p. 2000570.
- Hasselmann, S., Hahn, L., Lorson, T., Schätzlein, E., Sébastien, I., Beudert, M., Lühmann, T., Neubauer, J.C., Sextl, G., Luxenhofer, R., & Heinrich, D.: Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel. Materials Horizons, 2021. 8(12): p. 3334–3344.
- Zhou, X.-Q., Mytiliniou, M., Hilgendorf, J., Zeng, Y., Papadopoulou, P., Shao, Y., Paradiz Dominguez, M., Zhang, L., Hesselberth, M.B.S., Bos, E., Siegler, M.A., Buda, F., Brouwer, A.M., Kros, A., Koning, R.I., Heinrich, D., & Bonnet, S.: Intracellular dynamic assembly of deep-red emitting supramolecular nanostructures based on the Pt...Pt metallophilic interaction. Advanced Materials, 2021. 33(37): p. 2008613.
- Hasselmann, S., Kopittke, C., Götz, M., Witzel, P., Riffel, J., & Heinrich, D.: Tailored nanotopography of photocurable composites for control of cell migration. RSC Advances, 2021. 11(8): p. 4286–4296.
- Chen, L.-Y., Apte, G., Lindenbauer, A., Frant, M., & Nguyen, T.-H.: Effect of HIT components on the development of breast cancer cells. Life, 2021. 11(8): p. 832.
- Miao, Q., Zurlo, E., de Bruin, D., Wondergem, J.A.J., Timmer, M., Blok, A.J., Heinrich, D.M., Overhand, M., Huber, M.I., & Ubbink, M.: A two-armed probe for in-cell DEER measurements on proteins. Chemistry – A European Journal, 2020. 26(71): p. 17128–17133.
- Miao, Q., Zurlo, E., de Bruin, D., Wondergem, A.J., Timmer, M., Blok, A.J., Heinrich, D.M., Overhand, M., Huber, M.I., & Ubbink, M.: A two-armed probe for in-cell DEER measurements on proteins. Chemistry – A European Journal, 2020. 26(71): p. 17128–17133.
- Tong, C., Wondergem, J.A.J., Heinrich, D., & Kieltyka, R.E.: Photopatternable, branched polymer hydrogels based on linear macromonomers for 3D cell culture applications. ACS Macro Letters, 2020. 9(6): p. 882–888.
- Wondergem, A.J., Witzel, P., Mytiliniou, M., Holcman, D., & Heinrich, D.M.: Topographical guidance of highly motile amoeboid cell migration. Biophysical Journal, 2020. 118(3): p. 606a.
- Tweedy, L., Witzel, P., Heinrich, D.M., Insall, R.H., & Endres, R.G.: Screening by changes in stereotypical behavior during cell motility. Scientific Reports, 2019. 9: p. 8784.
- Witzel, P., Götz, M., Lanoiselée, Y., Franosch, T., Grebenkov, D.S., & Heinrich, D.M.: Heterogeneities shape passive intracellular transport. Biophysical Journal, 2019. 117(2): p. 203–213.
- Ramijan Carmiol, A.K., Ultee, E., Willemse, J.J., Zhang, Z., Wondergem, A.J., van der Meij, A., Heinrich, D.M., Briegel, A., van Wezel, G.P., & Claessen, D.: Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes. Nature Communications, 2018. 9: p. 5164.
- Paulitschke, P., Keber, F., Lebedev, A., Stephan, J., Lorenz, H., Hasselmann, S., Heinrich, D.M., & Weig, E.M.: Ultraflexible nanowire array for label- and distortion-free cellular force tracking. Nano Letters, 2019. 19(4): p. 2207–2214.
- Noteborn, W.E.M., Wondergem, A.J., Lurchenko, A., Chariyez-Prinz, F., Donato, D.M., Voets, I.K., Heinrich, D.M., & Kieltyka, R.E.: Grafting from a hybrid DNA-covalent polymer by hybridization chain reaction. Macromolecules, 2018. 51(14): p. 5157–5164.
- Askes, S.H.C., Bossert, N., Bussmann, J., Talens, V.S., Meijer, M.S., Kieltyka, R.E., Kros, A., Bonnet, S.A., & Heinrich, D.M.: Dynamics of dual-fluorescent polymersomes with durable integrity in living cancer cells and zebrafish embryos. Biomaterials, 2018. 168: p. 54–63.
- Heinrich, D.M., Götz, M., & Sackmann, E.: Die Zelle – erstaunlich physikalisch. Physik in unserer Zeit, 2018. 49(2): p. 64–70.
- van der Wel, C.M., Bossert, N., Mank, Q.J., Winter, M.G.T., Heinrich, D.M., & Kraft, D.J.: Surfactant-free colloidal particles with specific binding affinity. Langmuir, 2017. 33: p. 9803–9810.
- van der Wel, C.M., Heinrich, D.M., & Kraft, D.J.: Microparticle assembly pathways on lipid membranes. Biophysical Journal, 2017. 113(5): p. 1037–1046.
- Bossert, N., de Bruin, D., Götz, M., Bouwmeester, D., & Heinrich, D.M.: Corrigendum: Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications. Scientific Reports, 2017. 7: p. 45882.
- Emmert, M., Witzel, P., Rothenburger-Glaubitt, M., & Heinrich, D.M.: Nanostructured surface of biodegradable silica fibers enhance directed amoeboid cell migration in a microtubule-dependent process. RSC Advances, 2017. 7: p. 5708–5714.
- Emmert, M., Witzel, P., & Heinrich, D.M.: Challenges in tissue engineering – towards cell control inside artificial scaffolds. Soft Matter, 2016. 12: p. 4287–4294.
- Bossert, N., de Bruin, D., Götz, M., Bouwmeester, D., & Heinrich, D.M.: Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications. Scientific Reports, 2016. 6: p. 37867.
- van der Wel, C.M., Vahid, A., Šarić, A., Idema, T., Heinrich, D.M., & Kraft, D.J.: Lipid membrane-mediated attraction between curvature-inducing objects. Scientific Reports, 2016. 6: p. 32825.
- Götz, M., Hodeck, K.F., Witzel, P., Nandi, A., Lindner, B., & Heinrich, D.M.: Probing cytoskeleton dynamics by intracellular particle transport analysis. The European Physical Journal Special Topics, 2015. 224(7): p. 1169–1183.
- Heinrich, D.: Tissue engineering: Stimulating cell dynamics. International Innovation: Health Partnership, 2015. 194: p. 99.
- Gorelashvili, M., Emmert, M., Hodeck, K., & Heinrich, D.M.: Amoeboid migration mode adaption in quasi-3D spatial density gradients of varying lattice geometry. New Journal of Physics, 2014. 16: p. 075012.
- Aquino, G., Tweedy, L., Heinrich, D.M., & Endres, R.G.: Memory improves precision of cell sensing in fluctuating environments. Scientific Reports, 2014. 4: p. 5688.
- Heinrich, D.M., Ecke, M., Jasnin, M., Engel, U., & Gerisch, G.: Reversible membrane pearling in live cells upon destruction of the actin cortex. Biophysical Journal, 2014. 106: p. 1079–1091.
- Tweedy, L., Meier, B., Stephan, J., Heinrich, D.M., & Endres, R.G.: Distinct cell shapes determine accurate chemotaxis. Scientific Reports, 2013. 3: p. 2602.
- Dupont, A., Gorelashvili, M., Schüller, V., Wehnekamp, F., Arcizet, D., Katayama, Y., Lamb, D.C., & Heinrich, D.M.: Single particle tracking in living cells: Is the third dimension worth it? Biophysical Journal, 2013. 104(2): p. 650a.
- Dupont, A., Gorelashvili, M., Schüller, V., Wehnekamp, F., Arcizet, D., Katayama, Y., Lamb, D.C., & Heinrich, D.M.: Three-dimensional single-particle tracking in live cells: News from the third dimension. New Journal of Physics, 2013. 15: p. 075008.
- Heinrich, D.M.: Ventures in time and space: Guiding cells towards regeneration. International Innovation: Health Partnership, 17–19, 2013.
- Meier, B., Zielinski, A., Weber, C., Arcizet, D., Youssef, S., Franosch, T., Rädler, J.O., & Heinrich, D.M.: Chemotactic cell trapping in controlled alternating gradient fields. Proceedings of the National Academy of Sciences of the United States of America, 2012. 108(28): p. 11417–11422.
- Arcizet, D., Capito, S., Gorelashvili, M., Leonhard, C., Vollmer, M., Youssef, S., Rappl, S., & Heinrich, D.M.: Contact-controlled amoeboid motility induces dynamic cell trapping in 3D-microstructured surfaces. Soft Matter, 2012. 8(5): p. 1473–1481.
- Nandi, A., Heinrich, D.M., & Lindner, B.: Distribution of diffusion measures from a local mean-square displacement analysis. Physical Review E, 2012. 86(2): p. 021926.
- Otten, M., Nandi, A., Arcizet, D., Gorelashvili, M., Lindner, B., & Heinrich, D.M.: Local motion analysis reveals impact of the dynamic cytoskeleton on intracellular subdiffusion. Biophysical Journal, 2012. 102(4): p. 758–767.
- Sackmann, E., Keber, F., & Heinrich, D.M.: Physics of cellular movements. Annual Review of Condensed Matter Physics, 2010. 1: p. 257–276.
- Engelke, H., Heinrich, D.M., & Rädler, J.O.: Probing GFP-actin diffusion in living cells using fluorescence correlation spectroscopy. Physical Biology, 2010. 7(4): p. 046014.
- Pelzl, C., Arcizet, D., Piontek, G., Schlegel, J., & Heinrich, D.M.: Axonal guidance by surface microstructuring for the investigation of vesicle transport. ChemPhysChem, 2009. 10(16): p. 2884–2890.
- Mahowald, J., Arcizet, D., & Heinrich, D.M.: Impact of external stimuli and cell micro-architecture on intracellular transport states. ChemPhysChem, 2009. 10(9–10): p. 1559–1566.
- Heinrich, D.M., Youssef, S., Schroth-Diez, B., Engel, U., Aydin, D., Blümmel, J., Spatz, J., & Gerisch, G.: Actin-cytoskeleton dynamics in non-monotonic cell spreading. Cell Adhesion & Migration, 2008. 2(2): p. 58–68.
- Arcizet, D., Meier, B., Sackmann, E., Rädler, J.O., & Heinrich, D.M.: Temporal analysis of active and passive transport in living cells. Physical Review Letters, 2008. 101(24): p. 248103.
- Heinrich, D.M., & Sackmann, E.: Active mechanical stabilization of the viscoplastic intracellular space of Dictyostelia cells by microtubule-actin crosstalk. Acta Biomaterialia, 2006. 2: p. 619–631.
- Sackmann, E., Reuther, A., & Heinrich, D.M.: Micromechanics of cells: Viscoelastic microscopy of cells. In: W. Gutkowski & T. A. Kowalewski (Eds.), Mechanics of the 21st Century, 2005: p. 313–328. Springer.
- Heinrich, D.: Wavelength selective optically induced charge storage in self-assembled semiconductor quantum dots. In: G. Abstreiter, M. C. Amann, M. Stutzmann, & P. Vogl (Eds.), Selected Topics of Semiconductor Physics and Technology, 2003.
- Heinrich, D., Hoffmann, J., Zrenner, A., Böhm, G., & Abstreiter, G.: Charging dynamics of self-assembled InAs quantum dots investigated by wavelength selective optically induced charge storage measurements. physica status solidi (b), 2001. 224(2): p. 357–360.
- Heinrich, D., Zrenner, A., Böhm, G., & Abstreiter, G.: Optical charging and de-charging of InAs quantum dots. In: D. Gershoni (Ed.), The Physics of Semiconductors, 2001. World Scientific.
- Heinrich, D., Hoffmann, J., Finley, J.J., Zrenner, A., Böhm, G., & Abstreiter, G.: Electron and hole storage in self-assembled InAs quantum dots. Physica E: Low-dimensional Systems and Nanostructures, 2000. 7(3–4): p. 484–488.
- Heinrich, D.M., Finley, J., Skalitz, M., Hoffmann, J., Zrenner, A., Böhm, G., & Abstreiter, G.: Optical charging of self-assembled InAs quantum dots. In: M. L. Sadowski, M. Potemski, & M. Grynberg (Eds.), Optical Properties of Semiconductor Nanostructures, 2000: p. 365–377. NATO Science Series III: High Technology, Vol. 81. Springer.
- Heinrich, D., Hoffmann, J., Finley, J.J., Zrenner, A., Böhm, G., & Abstreiter, G.: Optically-induced charge storage in self-assembled InAs quantum dots. Thin Solid Films, 2000. 380(1–2): p. 192–194.
- Finley, J.J., Skalitz, M., Heinrich, D., Arzberger, M., Zrenner, A., Böhm, G., & Abstreiter, G.: Electrical detection of charge storage in self-assembled InAs quantum dots. In: D. Gershoni (Ed.), The Physics of Semiconductors, 1999. World Scientific.
- Richter, A., Süptitz, M., Heinrich, D., Lienau, Ch., Elsaesser, T., Ramsteiner, M., Nötzel, R., & Ploog, K.H.: Exciton transport into single quantum wires studied by time-resolved low-temperature near-field scanning optical microscopy. Applied Physics Letters, 1998. 73(15): p. 2176.
- Lienau, Ch., Richter, A., Behme, G., Süptitz, M., Heinrich, D., Elsaesser, T., Ramsteiner, M., Nötzel, R., & Ploog, K.H.: Nanoscale mapping of confinement potentials in single semiconductor quantum wires by near-field spectroscopy. Physical Review B, 1998. 58(4): p. 2045.
- Lienau, Ch., Richter, A., Heinrich, D.M., Elsaesser, T., Ramsteiner, M., Nötzel, R., & Ploog, K.H.: Time-resolved near-field spectroscopy of the carrier dynamics in single GaAs nanostructures. In: T. Elsaesser, J. G. Fujimoto, D. A. Wiersma, & W. Zinth (Eds.), Ultrafast Phenomena XI, 1998: p. 168–170. Springer Series in Chemical Physics, Vol. 63. Springer.
Alle Publikationen von Frau Prof. Dr. Doris Heinrich finden Sie auch hier.
- Mitarbeiter
Mitarbeiter Fachbereich Analysenmesstechnik: Danny Echtermeyer, Dr. Dieter Frense, Dr. Thomas Fuhs, Chris Jörg Gansauge,
Prof. Dr. Doris Heinrich (Leitung), Doreen Lisicki, Dikshita Madkatte, Daniel Martin, PD Dr. habil. Thi-Huong Nguyen, Felix Petzsch-Weinhold,
Prof. Dr. Uwe Pliquett, Katharina Schieke, Marcus Soter, Martina Weber
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Prof. Dr. Doris Heinrich
Institutsdirektorin / Sprecherin des Vorstandes
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